The educational video “Unraveling FOP: How a Single Mutation Hijacks Bone Formation” explores the molecular and cellular mechanisms underlying Fibrodysplasia Ossificans Progressiva (FOP)—a rare genetic disorder in which soft tissues gradually turn into bone. This video explains how a single point mutation in the ACVR1 (ALK2) gene alters normal bone morphogenetic protein (BMP) signaling, leading to uncontrolled bone formation in muscles, tendons, and ligaments.
Designed to communicate complex molecular genetics in an accessible yet scientifically accurate way, the video guides viewers through the pathophysiology of FOP, illustrating how this mutation “hijacks” developmental pathways that are normally tightly regulated. It highlights current research directions aimed at understanding this misregulated signaling cascade and potential therapeutic strategies to prevent heterotopic ossification.
Created using Fliki for narration and video editing and BioRender for high-quality molecular and cellular visuals, the presentation provides a clear and engaging learning experience for students, biomedical researchers, and healthcare professionals interested in genetics, molecular biology, and rare disease research.
Citations:
- Created in BioRender. FOP Pathway. Guerrero, A., Perez, S.,(2025) https://BioRender.com/dzfo9q6
- “Unraveling FOP: How a Single Mutation Hijacks Bone Formation.” Fliki AI, uploaded by Guerrero, A., Perez, S. April 21, 2025, https://app.fliki.ai/editor/67c65630018b7329ffa7204b
