StMU Research Scholars

Featuring Scholarly Research, Writing, and Media at St. Mary's University
November 9, 2025

Double Trouble: The Sodium-Potassium Pump’s Role in Heart & Neurological Disease

References

Images were created in https://BioRender.com

  1. Congestive heart failure. (2025, September 24). Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/17069-heart-failure-understanding-heart-failure
  2. Dhalla, N. S., Elimban, V., & Adameova, A. D. (2024). Role of NA+-K+ ATPASE alterations in the development of heart failure. International Journal of Molecular Sciences, 25(19), 10807. https://doi.org/10.3390/ijms251910807
  3. Despa, S., Islam, M. A., Weber, C. R., Pogwizd, S. M., & Bers, D. M. (2002). Intracellular NA + concentration is elevated in heart failure but NA/K pump function is unchanged. Circulation, 105(21), 2543–2548. https://doi.org/10.1161/01.cir.0000016701.85760.97
  4. Familial hemiplegic migraine: MedlinePlus Genetics. (2024). Medlineplus.gov. https://medlineplus.gov/genetics/condition/familial-hemiplegic-migraine/#resources
  5. Girishwaran M, & Lulu, S. S. (2025). Migraine is a dysfunction of neuronal potassium ion channels. Frontiers in Neurology, 16. https://doi.org/10.3389/fneur.2025.1622994‌
  6. Jen, J. C. (1993). Familial Hemiplegic Migraine (M. P. Adam, H. H. Ardinger, R. A. Pagon, S. E. Wallace, L. J. Bean, G. Mirzaa, & A. Amemiya, Eds.). PubMed; University of Washington, Seattle. https://www.ncbi.nlm.nih.gov/books/NBK1388/
  7. Journal of the American Heart Association, 11(7). https://doi.org/10.1161/jaha.121.021814
  8. Kjeldsen, K. (n.d.). Myocardial Na,K-ATPase: Clinical aspects. https://pmc.ncbi.nlm.nih.gov/articles/PMC2716273/
  9. Schwinger, R. H. G., Bundgaard, H., Müller-Ehmsen, J., & Kjeldsen, K. (2003). The Na, K-ATPase in the failing human heart. Cardiovascular Research, 57(4), 913–920. https://doi.org/10.1016/s0008-6363(02)00767-8
  10. ‌Staehr, C., Rohde, P. D., Nikolaj Thure Krarup, Steffen Ringgaard, Laustsen, C., Johnsen, J., Nielsen, R., Beck, H. C., Morth, J. P., Lykke‐Hartmann, K., Jespersen, N. R., Abramochkin, D., Nyegaard, M., Bøtker, H. E., Aalkjaer, C., & Vladimir Matchkov. (2022). Migraine‐Associated Mutation in the Na,K‐ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function.
  11. Types of heart failure. (2025, May 21). www.heart.org. https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure/types-of-heart-failure

Acknowledgements

I would like to acknowledge Dr. Shackleford for her support and detailed feedback on the development of our infographic project. Her expertise in this field and her comments helped shape the quality and depth of our research, motivating us to think beyond surface-level knowledge and really understand the ‘why’ and ‘how’ of our topic. Additionally, I would like to thank my peers and my partner for their cooperation and dedication in helping me organize my thoughts and strengthen the visual parts of my data. Their collaboration made this project very enjoyable and rewarding, which has improved my knowledge of the Sodium-Potassium pump and its functions/dysfunctions. I now better understand how the sodium-potassium pump can be linked to diseases, especially congestive heart failure and familial hemiplegic migraine, which I can apply in the future to strengthen my expertise in medicine. I am very grateful for the opportunity to have research published, and I look forward to publishing more research in the future.

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