StMU Research Scholars

Origin Theories of Syphilis

The first meeting of Columbus and his Spanish explorers with the natives of the Caribbean was one to be remembered. Posterity has pictured this scene as one of happy explorers sharing food with the natives; but the truth of that first encounter, and its aftermath for the natives, was far from happy. Through the exchange, the natives received a number of diseases for which they had no immunities; and one of the largest demographic disasters the world has ever seen was the result. But the disease syphilis was also exchanged, between the New World and the Old World. The nature of this exchange of syphilis, though, is full of debate and speculation concerning its origins.

The Indians astonished at the eclipse of the moon foretold by Columbus, illustration from ‘A New Universal Collection of Authentic and Entertaining Voyages and Travels’ by Edward George Cavendish,1770 (engraving) | Courtesy of The Bridgeman Art Library

Syphilis was one of the most notable examples of New World diseases that traveled to the Old World in what historians now call the Columbian Exchange. There are two different theories for how syphilis was spread. The Columbian hypothesis claims that syphilis was spread by Columbus and his crew on their voyage back to the Old World. Once they contracted it from natives in the Americas, the crew then went back to the Old World. The evidence that supports this hypothesis is the assumption that Columbus’s crew members, once returned back to Spain, joined Spain’s war effort in Naples, exposing the disease to local prostitutes. Once exposed to syphilis, the disease was spread quite easily from the prostitutes to other soldiers and locals, thus increasing the spread of syphilis in the Old World. This explanation for the spread of syphilis is possible because some of Columbus’s crew did in fact join the war effort against Naples and most likely they did mingle with the locals there causing the spread of syphilis.1

The other theory, the Pre-Columbian hypothesis, was that syphilis had always been an Old World disease, but its spread was only exacerbated through the interaction of the natives and Europeans during the Columbian Exchange. This second theory is plausible since there is evidence of pre-Columbian Old World skeletons that show scars similar to syphilis scars. What this means is, since the skeletons from the Old World have scars and written accounts of symptoms similar to syphilis that pre-date the first exchange between Columbus and the Americas, syphilis could have possibly been an Old World disease. Now this theory of syphilis’ origin is a matter of syphilis being yet another disease that was spread from the explorers. Both of these hypotheses are plausible.2

Although these two theories for the origin of syphilis have been debated for decades, a less know third theory has emerged. This third theory suggests that syphilis was both an Old World and a New World disease. Syphilis is thought to “evolved simultaneously with human.”3 In other words, when the respectively different populations of humans evolved, the disease known as syphilis grew with the population in both hemispheres. This theory, though, is mostly unknown because of the two older and more established theories, which have dominated the discussions on syphilis’ origins. This third theory puts an interesting twist on this long debate.4

Through the exchange of syphilis, the lives of natives and explorers were changed in a drastic way. The picture of happy natives and explorers sharing food is one everyone has seen but the different narrative of the debate of syphilis’ origins is one many have not seen. The three theories of syphilis are all very real and possible, which is why the debate of syphilis is such a topic that can cause arguments. The debate over syphilis’ origins is one that will most likely be researched and hypothesized over for many years to come.



  1. Nathan Nunn and Nancy Qian, “The Columbian Exchange: A History of Disease, Food, and Ideas,” The Journal of Economic Perspectives 24, no. 2 (2010): 166-167.
  2. Nathan Nunn and Nancy Qian, “The Columbian Exchange: A History of Disease, Food, and Ideas,” The Journal of Economic Perspectives 24, no. 2 (2010): 167.
  3. Brenda J. Baker et al., “The Origin and Antiquity of Syphilis: Paleopathological Diagnosis and Interpretation and Comments and Reply,” Current Anthropology 29, no. 5 (1988): 703–706.
  4. Brenda J. Baker et al., “The Origin and Antiquity of Syphilis: Paleopathological Diagnosis and Interpretation and Comments and Reply,” Current Anthropology 29, no. 5 (1988): 704.

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53 Responses

  1. Hi Esperanza, Im very fascinated by this article, as I did not realize how far syphilis went back. As far as the Europeans possibly bringing that disease to the Natives, I don’t find that hard to believe , Iv’e been reading this book American History by Alan Brinkley, Iv’e noticed that the Europeans really were to blame for bringing the natives many different diseases and even taking out a lot of their population. Nice job on your article!

  2. The story and consequences of the spread of diseases that came with the conquer of the New World is known by everyone. Instead, I was not aware of the diseases that spread in the Old World because of the contacts that Europeans had with native Americans. One of this diseases is Syphilis and, as the author states, there is a lot of debate about how this disease arrived to Europe. Any of the 3 theories presented can be the true one, but I think that each of them has some truth in it, and what is clear is that the disease already existed in the New World. In any case, the spread of diseases without control has always supposed a threat to human health around the globe, because of the fear of a global Pandemic. Prove of this is our actual situation, which will be remembered as the first Pandemic that has reached all the parts of the World.

  3. I always knew that Europeans had brought along with them diseases into the New World, yet I found it fascinating to know more specifically on syphilis. Crazy to think that the disease origins still has many unknown factors. This article definitely brought explications but how it affected the Natives is interesting to know about. Reminds me of Covid-19 and how there are still many unknown things about the disease and lots of research being done to help stop the spread and eventually prevent the death of thousands of more people.

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